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Retatrutide (LY-3437943) is an investigational drug developed for the treatment of obesity and type 2 diabetes. It acts as a triple receptor agonist, targeting GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and GCGR (glucagon receptor). Structurally, it is a 39-amino acid peptide engineered on a GIP backbone, which enables its multi-receptor activity. Additionally, it is resistant to degradation by the DPP-4 enzyme, which normally breaks down GLP-1 and GIP.

Indications
Retatrutide is intended for improving glycemic control in patients with type 2 diabetes, as well as for supporting weight loss when combined with proper diet and physical activity.

Mechanism of Action
Retatrutide produces its effects through several complementary pathways:
It mimics the natural GLP-1 hormone released after food intake, enhancing satiety signals in the brain. This leads to reduced appetite and helps limit caloric intake.
By activating GLP-1 and GCGR receptors, it increases insulin secretion while modulating glucagon levels, contributing to improved blood glucose regulation and more efficient energy utilization rather than fat storage. This metabolic shift supports weight reduction and may also have a positive effect on blood pressure.
It helps prevent rapid drops in blood glucose levels, which are often associated with cravings and uncontrolled eating behavior. As a result, patients may find it easier to maintain consistent dietary habits.

Clinical Data
Clinical studies indicate that Retatrutide can initiate noticeable weight reduction within approximately 4 weeks. In trials involving adults with overweight or obesity (without diabetes), total body weight loss ranged from 15% to 35% by the end of the treatment period.

Acheter Retatrutide 10 mg | Hilma Biocare. Traitement du diabète de type 2 et perte de poids.
Le retatrutide est utilisé pour améliorer le contrôle glycémique en association avec un régime alimentaire et de l’exercice.

Acheter Retatrutide 10mg | Hilma Biocare

Retatrutide